pI: 6.0921 |
Length (AA): 167 |
MW (Da): 19435 |
Paralog Number:
1
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
45 | 167 | 1twf (I) | 2 | 118 | 19.00 | 0 | 0.75 | 0.43 | 1.33 |
43 | 76 | 1m2v (B) | 224 | 257 | 35.00 | 0.12 | 0.84 | 0.618093 | 0.07 |
47 | 167 | 1twf (I) | 4 | 118 | 28.00 | 0 | 1 | 0.979751 | 0.61 |
107 | 163 | 1qyp (A) | 7 | 57 | 27.00 | 0 | 0.63 | 0.612517 | -0.7 |
122 | 162 | 4ci2 (B) | 325 | 385 | 41.00 | 0.34 | 0.11 | 0.029009 | 1.45 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128243)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G16265 | RNA polymerases subunit NRP(B/D/E)9b |
Arabidopsis thaliana | AT3G16980 | DNA-directed RNA polymerases II, IV and V subunit 9A |
Babesia bovis | BBOV_II007540 | DNA-directed RNA polymerase 2 subunit, putative |
Brugia malayi | Bm1_52995 | DNA-directed RNA polymerase II 15.1 kDa polypeptide, putative |
Candida albicans | CaO19.9816 | similar to S. cerevisiae RPB9 (YGL070C) RNA polymerase II core subunit |
Candida albicans | CaO19.2276 | similar to S. cerevisiae RPB9 (YGL070C) RNA polymerase II core subunit |
Caenorhabditis elegans | CELE_Y97E10AR.5 | Protein RPB-9 |
Cryptosporidium hominis | Chro.30221 | DNA-directed RNA polymerase 2 subunit |
Cryptosporidium parvum | cgd3_1870 | DNA-directed RNA polymerase 2 subunit |
Dictyostelium discoideum | DDB_G0268306 | RNA polymerase II core subunit |
Drosophila melanogaster | Dmel_CG3284 | RNA polymerase II 15kD subunit |
Echinococcus granulosus | EgrG_000372700 | RNA polymerase II 15 kDa subunit |
Entamoeba histolytica | EHI_056690 | DNA-directed RNA polymerase II subunit, putative |
Echinococcus multilocularis | EmuJ_000372700 | RNA polymerase II 15 kDa subunit |
Homo sapiens | ENSG00000105258 | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa |
Leishmania braziliensis | LbrM.28.0130 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Leishmania donovani | LdBPK_280120.1 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Leishmania infantum | LinJ.28.0120 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Leishmania major | LmjF.28.0120 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Leishmania mexicana | LmxM.28.0120 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Loa Loa (eye worm) | LOAG_00779 | hypothetical protein |
Mus musculus | ENSMUSG00000019738 | polymerase (RNA) II (DNA directed) polypeptide I |
Neospora caninum | NCLIV_022210 | hypothetical protein |
Oryza sativa | 4331295 | Os03g0102200 |
Oryza sativa | 4352511 | Os12g0560400 |
Oryza sativa | 4343902 | Os07g0615800 |
Plasmodium berghei | PBANKA_0203300 | DNA-directed RNA polymerase II subunit RPB9, putative |
Plasmodium falciparum | PF3D7_0110400 | DNA-directed RNA polymerase II subunit RPB9, putative |
Plasmodium knowlesi | PKNH_0203500 | DNA-directed RNA polymerase II subunit RPB9, putative |
Plasmodium vivax | PVX_081277 | DNA-directed RNA polymerase 2, putative |
Plasmodium vivax | PVX_136260 | unspecified product |
Plasmodium yoelii | PY00422 | DNA-directed RNA polymerase ii 15.1 kDa polypeptide |
Saccharomyces cerevisiae | YGL070C | DNA-directed RNA polymerase II core subunit RPB9 |
Schistosoma japonicum | Sjp_0089430 | ko:K03017 DNA-directed RNA polymerase II subunit I, putative |
Schistosoma mansoni | Smp_067090 | DNA-directed RNA polymerase II |
Schmidtea mediterranea | mk4.001708.02 | DNA-directed RNA polymerase II subunit RPB9 |
Schmidtea mediterranea | mk4.025637.00 | |
Schmidtea mediterranea | mk4.001721.00 | |
Trypanosoma brucei gambiense | Tbg972.11.8320 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Trypanosoma brucei | Tb11.v5.0255 | DNA-directed RNA polymerase II, subunit 9, putative |
Trypanosoma cruzi | TcCLB.511153.130 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Trypanosoma cruzi | TcCLB.506779.60 | DNA-direcetd RNA polymerase II, subunit 9, putative |
Toxoplasma gondii | TGME49_202690 | DNA-directed RNA polymerase II RPB9 |
Theileria parva | TP02_0205 | DNA-directed RNA polymerase II subunit, putative |
Trichomonas vaginalis | TVAG_212550 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.5180 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5180 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5180 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.5180 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0203300 | Plasmodium berghei | Slow | plasmo |
TGME49_202690 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.